There's also an association between sunlight exposure and the risk of MS.

Experts need to better understand how vitamin D might affect MS. Research suggests that vitamin D has a positive effect on the immune system.

MS develops when the immune system attacks the coating that protects the nerve cells, known as myelin. While vitamin D supplements appear to be safe for people with MS, high doses can lead to changes in calcium levels. More research is needed to determine whether vitamin D supplements are helpful. Taking the supplement also may lengthen the time it takes to progress from relapsing-remitting multiple sclerosis to the secondary-progressive phase. New scarring can be seen on MRI and are known as radiographic lesions. Taking vitamin D also may lower the risk of relapse and may decrease new scarring in the nervous system. Also, symptoms may occur less often, which may improve quality of life. People who have MS and take vitamin D supplements may have symptoms that aren't as bad as they would be if they didn't take vitamin D. (J Am Board Fam Med 2009 22:698 –706.Some studies also suggest that vitamin D may benefit people who already have MS. Unfortunately, little evidence guides clinicians on when to screen for vitamin D deficiency or effective treatment options. New recommendations from the American Academy of Pediatrics address the need for supplementation in breastfed newborns and many questions are raised regarding the role of maternal supplementation during lactation. Although it is well known that the combination of vitamin D and calcium is necessary to maintain bone density as people age, vitamin D may also be an independent risk factor for falls among the elderly. Low vitamin D levels are associated with increased overall and cardiovascular mortality, cancer incidence and mortality, and autoimmune diseases such as multiple sclerosis.

In addition, recent epidemiologic studies have observed relationships between low vitamin D levels and multiple disease states. Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism and seems to have some anti-inflammatory and immune-modulating properties.

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